Insulin glargine medical definition merriamwebster medical. Lantus insulin glargine is a recombinant human insulin analog with a duration of action up to 24 hours. Some insulin glargine drug interactions can result in. Oct 31, 2018 hypersensitivity to insulin glargine or any of the product componentsduring episodes of hypoglycemiasafety and efficacy of insulin glargine 100 unitsml u100 have not been established in patients with type 1 diabetes younger than 6 years or pediatric patients with type 2 diabetes. Dec 17, 2007 characteristics of glargine in type 2 diabetics the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Enhances transmembrane passage of glucose across cell membranes. Pro and juniorstar or the user manual for lantus solostar for. Always look at your insulin glargine before you inject it. Im administration or cri of regular insulin has long been accepted as ideal initial treatment for feline diabetic ketoacidosis dka.
Insulin glargine lantus insulin glargine injection. Oten insulin glargine containing the indicated percentage of high molecular weight proteins may be prepared by incubating insulin glargine at 100 for 1. Insulin glargine is a longacting form of insulin that is slightly. Lantus insulin glargine injection for subcutaneous injection. Insulin glargine is a longacting type of insulin that works slowly, over about 24 hours. Also, insulin helps us store energy that we can use later. Insulin analogues are structurally similar to human insulin except for minor amino acid modifications to change the pk properties. Plus watch the video to learn how to use the lantus solostar. A recombinant human insulin analog with a long duration of action. Listing a study does not mean it has been evaluated by the u.
Lantusinsulin glargine injection rdna origin is a recombinant. It is the first longacting analog of human insulin to be approved for clinical use. In glargines case, glycine and two arginines are part of the genetic recombination that helps to produce the insulin. Lantus consists of insulin glargine dissolved in a clear aqueous fluid. All trials are openlabel because nph is cloudy whereas insulin glargine is clear. Carryover insulin and insulin analogs are known to show significant carryover in hplc due to nonspecific binding to the stationary phase. This analog is soluble in the acidic solution in which it is packaged but relatively insoluble in the physiologic ph of the extracellular fluid. Insulin is one of many hormones that help the body turn the food we eat into energy. Characteristics of glargine in type 2 diabetics full text. Insulin glargine is a longacting insulin that starts to work several hours after injection and keeps working evenly for 24 hours. Hypoglycemic pregnancy risk category c action longacting insulin form. Never share a lantus solostar prefilled pen between patients, even if the needle is changed. Feb 28, 2020 insulin glargine is a longacting insulin that starts to work several hours after injection and keeps working evenly for 24 hours insulin glargine is used to improve blood sugar control in adults and children with diabetes mellitus.
Lantus, toujeo insulin glargine dosing, indications. Capitals indicate lifethreatening, underlines indicate most frequent. Insulin glargine should be injected into the fatty tissue under the skin subcutaneously. Lantus insulin glargine dose, indications, adverse effects. Insulin glargine is a recombinant human insulin analog that is a longacting up to 24hour duration of.
Insulin glargine lantus and cancer lecom education system. Quantitation of insulin glargine in human plasma with a. Insulin glargine drug bnf content published by nice. Insulin glargine, marketed under the names lantus among others, is a longacting insulin, used in the management of type i and type ii diabetes. Insulin glargine should be injected into the fatty tissue under the.
Three examples are insulin glargine, lispro and aspart figure 1. Insulin injection sites and side effects, insulin dosage lantus. Hyperglycemia or hypoglycemia with changes in insulin regimen. Insulin glargine is a recombinant human insulin analog that is a longacting up to 24hour duration of action, parenteral bloodglucoselowering agent. Insulin glargine is used to treat type 1 or type 2 diabetes in adults, and type 1 diabetes children who are at least 6 years old. Learn about insulin injection sites and possible side effects, insulin dosage, vials and pens. Lantus is contraindicated during episodes of hypoglycemia and in patients hypersensitive to insulin glargine or one of its excipients. Hypersensitivity to insulin glargine or any of the product componentsduring episodes of hypoglycemiasafety and efficacy of insulin glargine 100 unitsml u100 have not been established. Insulin glargine insuelin glarjeen what does it do. The next generation involved combining neutral suspensions of insulin with zinc ions andor highly basic proteins such as protamines 52, 54. It precipitates in the neutral environment of subcutaneous tissue and is thus gradually absorbed into the bloodstream. This article is published with open access at abstract the epochmaking discovery of insulin heralded a new dawn in the management of diabetes. Insulin glargine 300 uml in the management of diabetes. Insulin is one of the most effective blood sugarlowering medication and can lower your a1c average blood sugar over time by up to 23%.
Insulin degludec versus insulin glargine in insulin naive patients with type 2 diabetes a 1year, randomized, treattotarget trial begin once long bernard zinman, md 1 athena philistsimikas, md 2 bertrand cariou, md, phd 3 yehuda handelsman, md 4 helena w. Apr 25, 2018 insulin glargine is a prescription medication used to treat type 1 and type 2 diabetes. Lantus insulin glargine dose, indications, adverse. It is not typically the recommended long acting insulin in. Insulin glargine lantus and cancer wednesday, 01 july 2009 three epidemiological studies observational studies conducted in sweden, germany and scotland, all suggesting a possible link. Millions of people every day count on lantus to help them manage their a1c and control their blood sugar. Characteristics of glargine in type 2 diabetics full. Insulin glargine lantus insulin glargine injection 100. Insulin glargine, a recombinant protein, is a longacting insulin analogue given daily to diabetes patients to help control blood sugar level. Product monograph lantus insulin glargine injection. Insulin from latin insula, island is a peptide hormone produced by beta cells of the pancreatic islets.
Use in patients with type 1 diabetes mellitus as basal insulin or use in patients with type 2 diabetes mellitus that experience recurrent nocturnal. Jan 01, 2017 insulin glargine is a longacting type of insulin that works slowly, over about 24 hours. Glycaemic control and hypoglycaemia with new insulin glargine 300 uml versus insulin glargine 100 uml in people with type 2 diabetes using. Lantus is a longacting insulin analog indicated to improve glycemic control in adults and pediatric patients with type 1 diabetes mellitus and in adults with type 2 diabetes mellitus. Issues in emerging health technologies issue 52 november 2003 insulin glargine.
It is not typically the recommended long acting insulin in the united kingdom. Chemically, insulin glargine is 21 agly30 b alarg30 b blarghuman insulin and has the empirical formula c267h404n72o78s6 and a molecular weight of 6063. Modified insulin glargine was purified from the marketed formulation by. Health professional information summary product information route of administration dosage form strength clinically relevant nonmedicinal ingredients subcutaneous solution for injection 100 uml.
The evolution of insulin glargine and its continuing. Insulin glargine is a manmade form of a hormone that is produced in the body. Insulin glargine is used to improve blood sugar control in adults and children with diabetes mellitus. Glycaemic control and hypoglycaemia with new insulin glargine 300 uml versus insulin glargine 100 uml in people with type 2 diabetes using basal insulin and oral antihyperglycaemic drugs. Lantus insulin glargine is a longlasting insulin that provides consistent, allday sugar control with just once or twice daily dosing. Insulin glargine is used to treat type 1 or type 2 diabetes in adults, and type 1 diabetes children who are at. Thanks for joining me on this walk through how to use the lantus solostar pen. Insulin glargine is a prescription medication used to treat type 1 and type 2 diabetes. Lantus insulin glargine rdna origin injection, 100 uml. It regulates the metabolism of carbohydrates, fats and protein by promoting the absorption of carbohydrates, especially glucose from the blood into liver, fat and skeletal muscle cells. Lowers blood glucose levels over an extended period of time by stimulating peripheral glucose uptake especially in muscle and fat tissue. Calibration curve for the quantitation of insulin glargine using microflow lcmsms.
Insulin glargine side effects, uses, dosage, overdose. Insulin analogues have received additional interest lately because many come offpatent in 2014, but also because novel analogues as. Glargine definition of glargine by medical dictionary. Insulin glargine lantus is an injectable form of longlasting insulin that is prescribed to regulate blood sugar levels in individuals with type 1 and type 2 diabetes. Do not use insulin glargine in an external insulin pump. Set an alarm, write yourself notes, or ask a friend or family member to remind you to inject at the same time each day. Insulin glargine is an extendedaction biosynthetic human insulin. Glargine lantus detemir levemir basal insulin is best starting insulin choice for most patients if fasting glucose above goal. Use in patients with type 1 diabetes mellitus as basal insulin or use in.
Insulin degludec versus insulin glargine in insulinnaive. Lantus insulin glargine is a longlasting insulin that provides. Biological medicines must be prescribed and dispensed by brand name, see biological medicines and biosimilar medicines, under guidance on prescribing. Dose adjustments and close metabolic monitoring is recommended if switching between insulin glargine preparations. Insulin glargine is a longacting insulin used to treat diabetes. Do not use your insulin glargine if it is colored, cloudy, or contains solid particles, or if the expiration date on the bottle has passed. The evolution of insulin glargine and its continuing contribution to. Insulin glargine, a longacting form of insulin, works by replacing the insulin that is normally produced by the. Insulin glargine is an analog of human insulin with cterminal elongation of the beta chain by two arginine residues and replacement of asparagine in position a21 by glycine.
Insulin glargine 300 uml monograph august 2015 updated version may be found at. Sigmaaldrich offers a number of insulin glargine products. Insulin glargine medical definition merriamwebster. This dose reduction will lower the likelihood of hypoglycemia see warnings and precautions 5.
The effects on longterm diabetic complications cannot be assessed because the trials do not last long enough. Insulin glargine is a bioengineered manmade injectable form of longacting insulin that is used to regulate sugar glucose levels in type 1 and type 2 diabetes. Humulin r u500 and insulin glargine as 300 unitsml toujeo. Lantus is a longacting insulin analog indicated to improve glycemic. The study is to determine the dose response relationship of insulin glargine in type 2 diabetes over a 24hour period and measuring the. Insulin glargine is used to improve blood sugar control in adults and children with. Additionally, the dose of basal glargine insulin required was higher in all. Nonformulary insulin glargine lantus will be covered on the prescription drug benefit when the following criteria are m et.
Insulin glargine, a longacting form of insulin, works by replacing the insulin that is normally produced by the body and by helping the body to use sugar for energy. Marketed as lantus, insulin glargine has been one of the bestselling. Concomitant use of insulin glargine and nph in type i diabetes. Highlights of prescribing information hyperglycemia or. Insulin glargine is a longacting insulin that starts to work several hours after injection and keeps working evenly for 24 hours insulin glargine is used to improve blood sugar control in adults. Lantus is an ultralente long acting analogue insulin the medical name for lantus, insulin glargine, is taken from how the dna of human insulin is modified to form the analogue.
So youre ready to begin first off, kudos to you on the decision to begin longacting insulin. It works by lowering levels of glucose sugar in the blood. The evolution of insulin glargine and its continuing contribution to diabetes care rolf hilgenfeld gerhard seipke harald berchtold david r. Pdf controlled release of modified insulin glargine from novel. This is done by using the glucose in the blood as quick energy. Insulin glargine is a selfinjectable solution used to control high blood sugar hyperglycemia in people with type 1 and type 2 diabetes. Insulin glargine has the following structural formula. Its available as the brandname drugs lantus, basaglar. Lantus insulin glargine 100 unitsml is the most prescribed long acting insulin. Insulin glargine is a longacting human insulin analog prepared using recombinant dna technology. In controlled clinical studies comparing insulin glargine to nph insulin, 15% of patients with type 1 and type 2 diabetes mellitus were 65 years of age or older. Oct 17, 2016 ykijarvinen h, bergenstal rm, bolli gb, et al. Carryover in the microflow lc method was reduced by using a.
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